Conduit Pharmaceuticals and Charles River Laboratories have announced a partnership to evaluate AZD1656, a glucokinase activator, in a preclinical model of systemic lupus erythematosus (SLE).

(Nasdaq: C Conduit Pharmaceuticals enters into exclusive license agreement with AstraZeneca for HK-4 Glucokinase activators AZD1656 and AZD5658 targeting autoimmune indications and myeloperoxidase ...

研究表明宫内生长迟缓的新生儿肝糖原显著降低，胎儿糖原蓄积稳态在胎儿发育中可能具有关键作用。本文通过猪模型研究发现：低体重胎儿在妊娠中期而非晚期发生肝脏糖原蓄积异常，这可能导致胎儿发育受阻（图1）。该研究为胎儿发育受阻提供了新的研究思路。

Chronic exposure to hyperglycemia can lead to cellular dysfunction that may become irreversible over time, a process that is termed glucose toxicity. Our perspective about glucose toxicity as it ...