The United States Food and Drug Administration has just approved the first-ever clinical trial that uses CRISPR-Cas13 RNA editing. Its aim is to treat an eye disease called wet age-related macular ...
Shares in Wave Life Sciences rose by 74% after it reported clinical data with a pioneering new RNA-editing therapy for alpha-1 antitrypsin deficiency (AATD). Wave claims this is the first clinical ...
This study is led by Professor Yongming Wang's research team from Fudan University, in collaboration with the team led by Professor Renjie Chai from ...
In molecular biology, RNA modifications were traditionally associated with static structural components like rRNAs and tRNAs. However, advancements such as antibody immunoprecipitation and ...
providing support for its function in enhancing deaminase-dependent viral RNA editing. Our study thus provides further insight into virus-host cell interactions mediating SARS-CoV-2 evolution. Host ...
This study reveals that ADAR1 dimerization influences the site-specificity of RNA editing without fully inhibiting its activity, offering new insights into how ADAR1 selects RNA targets and ...