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This report describes the impact of glycosylation on the pharmacokinetics, pharmacodynamics, therapeutic activity, and production (biomanufacturing) of therapeutic proteins using several examples that ...

Hyperglycemia increases flux through the hexosamine pathway. From Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820, 2001.

These pathways include nuclear factor- B, p38 mitogen-activated protein kinase, NH 2-terminal Jun kinases/stress-activated protein kinases, hexosamines, and others. In addition, there is evidence ...