Statins lower plasma cholesterol by upregulating LDL receptor gene expression and are consequently relatively ineffective in homozygous familial hypercholesterolemia (HoFH). The standard treatment ...

No writing assistance was utilized in the production of this manuscript. Lipid metabolism in homozygous familial hypercholesterolemia (HoFH) is abnormal owing to lack of functional LDL receptors ...

Heterozygous familial hypercholesterolemia was associated with increased type 2 diabetes risk, especially among those with obesity and statin use.

Adaptimmune is a fully integrated cell therapy company working to redefine how cancer is treated. With its unique engineered T cell receptor (TCR) platform, the Company is developing personalized ...

This study provides valuable evidence for the mechanism underlying KCNC1-related developmental and epileptic encephalopathy. The authors have generated and characterized a new knock-in mouse with a ...

Lexeo Therapeutics, Inc. (LXEO – Research Report), the Healthcare sector company, was revisited by a Wall Street analyst yesterday. Analyst ...

Experts highlighted that Pakistan is one of the leading countries for cousin marriages in the world, resulting in genetic ...

Learn about typical dosages of atorvastatin oral tablet for high cholesterol and heart-related risks, including what’s considered a low dose versus a high dose of this statin.

Mitochondrial DNA (mtDNA)-encoded RNA molecules undergo extensive processing to generate mature RNA, including removal of ...

I have always enjoyed the thrill and discipline of staying fit. I played four sports in high school, was a walk-on quarterback at the University of Alabama and took up running in my 20s. This began ...