The immunoregulatory molecule indoleamine 2,3-dioxygenase 1 (IDO1)—which catalyzes the first, rate-limiting step of Trp degradation through the kynurenine (Kyn) pathway—is highly expressed in many ...

Indoleamine 2,3-dioxygenase (IDO), which catalyzes the breakdown of the essential amino acid tryptophan into kynurenine, is understood to have a key role in cancer immunotherapy because of its role in ...