To understand the potential impact on course of inflammation, the aim of this study was to investigate whether C3d, a cleavage-product of C3, triggers interleukin (IL)-1β secretion via activation of ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...

2 Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands Objectives Acute gouty arthritis is caused by endogenously formed monosodium urate (MSU) ...

Notably, VTX3232 is an oral, selective, central nervous system (CNS)-penetrant NLRP3 inhibitor, which is being developed for various neuroinflammatory and neurodegenerative indications ...