Notably, Cohort 1 confirmed Phase 0 observations of pharmacodynamic activity in patients with high baseline expression of miR-10b, achieving a 66% inhibition at 24 hours post-infusion. TTX-MC138 ...

Notably, Cohort 1 demonstrated a 66 percent inhibition of miR-10b at 24 hours post-infusion, which is similar to previous findings, and Cohort 2 showed increased activity with the higher dose ...

Preliminary analyses indicate that TTX-MC138 has demonstrated pharmacodynamic activity, with a 66% inhibition of miR-10b expression at 24 hours post-infusion, similar to findings from the earlier ...