The authors correlated Cryo-EM structures and mutation patterns in whole genome sequencing data to show how topological factors in the genome can limit repair protein accessibility leading to enhanced ...

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Department of Chemistry, King’s College London, Britannia House, 7 Trinity Street, London SE1 1DB, U.K.

1 Department of Internal Medicine, Policlinico IRCCS San Donato, University of Milan, Via Morandi, 30, 20097 San Donato (MI), Italy 2 Department of Internal Medicine ...

More information: Elana Bryan et al, Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains, Molecular Cell (2024). DOI: 10.1016/j.molcel.2024.12.002 Journal ...

Because of its ability to regulate the abundance of selected proteins the ubiquitin proteasome system (UPS) plays an important role in neuronal and synaptic plasticity. As a result various stages of ...

This study provides important new insights into the contributions of local DNA features to the complex molecular mechanisms and dynamics of copy number variation (CNV) formation during adaptive ...