Centre for Inflammation Research, The University of Edinburgh, EH16 4UU Edinburgh, U.K. IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU Edinburgh, U.K.

This important study identifies a short amino acid sequence that, when fused in multimeric form to the amino termini of luminal ER proteins, initiates proteasomal degradation via the Hrd1 ER quality ...

Antibiotics that inhibit protein synthesis are known to have some degree of antivirulence effects. Macrolides bind reversibly to 23S ribosomal RNA (rRNA) of the 50S subunit of bacterial ribosome ...