Phenformin, the other previously available biguanide, was withdrawn from the market in 1977 because of an association with lactic acidosis. Buformin, another biguanide, is not available in the ...

If you are using diabetes medications, tell your healthcare provider about any herbal supplements you’re taking to avoid interactions. Phenformin was introduced in 1957 at the same time as metformin ...

Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People’s Republic of China Department of Chemistry, National University of ...

Biguanides are a class of medications used to treat type 2 diabetes and other conditions. They work by reducing the production of glucose that occurs during digestion. Metformin is the only ...

Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many of the selective pressures encountered by tumor cells, such as exposure to anticancer therapies, navigation ...

Ferroptosis induces significant changes in mitochondrial morphology, including membrane condensation, volume reduction, cristae alteration, and outer membrane rupture, affecting mitochondrial function ...