They may be part of signal transduction cascades in which one kinase phosphorylates one kinase (making it a phosphoprotein) or multiple kinases, to amplify and propagate a cellular signal.

Background Tyrosine kinase 2 (Tyk2) is a member of the JAK family that phosphorylates STAT proteins downstream of the IL-12, IL-23 and the Type I interferon receptor. Tyk2 genetic variants have been ...

The ATP produced in the previous pathway phosphorylates PGA, which is then reduced by NADPH to glyceraldehyde 3-phosphate (GAP). For every six molecules of GAP produced, five are used to replenish ...

This valuable study reports the first characterization of the CG14545 gene in Drosophila melanogaster, which the authors name "Sakura." Acting during germline stem cell fate and differentiation, ...

Richard J. Johnson; Takahiko Nakagawa; L. Gabriela Sanchez-Lozada; Mohamed Shafiu; Shikha Sundaram; Myphuong Le; Takuji Ishimoto; Yuri Y. Sautin; Miguel A. Lanaspa ...

1 Department of Orthopaedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China 2 Department of Orthopedics Surgery, Shanghai ...

In studying GBP1 in uninfected cells, we have found that an IFNy-induced kinase, PIM1, phosphorylates GBP1 driving it towards its locked state bound to a cellular scaffold protein. PIM1 is an ...

In line with the proposal for amending the warning statement of Insulin Lispro Ultrarapid Injection 100 IU & 200 IU, the ...