综上所述，该研究展示了如何通过整合基因组和蛋白组学数据、因果推断与先进人工智能蛋白质三维结构预测工具，填补该领域的关键空白，为阿尔茨海默病的下一代研究奠定了坚实基础。通过识别蛋白标志物的三维结构变化，促进了对疾病关键通路的靶向干预研究，为精准医学带来 ...

Introduction to Mendelian randomization, the problems with using traditional observational studies to investigate causality, and Randomized controlled trials as the gold standard for causal research.

This innovative programme aims to extend the now widely utilized Mendelian Randomization (MR) paradigm in ways that will substantially increase its utility in population and clinical sciences. The ...

Mendelian randomization (MR) is a relatively new form of evidence synthesis and causal inference that is of growing importance in observational epidemiology. The approach can be viewed as an ...

Greatly expanded, this new edition requires only an elementary background in discrete mathematics and offers a comprehensive introduction to the role of randomization and probabilistic techniques in ...

Genetic evidence suggests that depression causes increased menstrual pain. The study utilized Mendelian randomization to ...

Researchers say pipeline could pave the way for more effective treatments for Alzheimer’s and other complex diseases.

A new study identifies a link between depression and dysmenorrhea, with sleeplessness as a potential mediator. Study: ...