On track to provide clinical data from the 12 mg dose cohort from the Phase 1b PIONEER trial of pociredir in SCD in mid-2025 and the 20 mg dose ...

On track to provide clinical data from the 12 mg dose cohort from the Phase 1b PIONEER trial of pociredir in SCD in mid-2025 ...

This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...

The government was plunged into a deep crisis this Saturday. The president appeared linked to a financial scam. A blow to the ...

Beyond the potential use of antiviral drugs to block hair loss, Ge says, “we believe the continuous arms race between retrotransposons and host repressors gives us a blueprint by which we could ...

The experiments themselves take thirty minutes and after a day of incubation, students can analyze color readouts to predict which guide RNAs were the most effective repressors by taking a picture ...

Each journal is staffed by professional editors who work in collaboration with one another and our international Editorial Advisory Boards of leading scientists. Please feel free to contact any of the ...

Objectives The circadian clocks are internal timing mechanisms that drive ∼24-hour rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc (IVD) show clear ...

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

This drug from Fulcrum Therapeutics binds to and inhibits EED, and the importance of this is to downregulate key fetal globin repressors. In turn, this leads to a boost in HbF production and thus ...

Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related mortality in women. Androgen receptor (AR) is frequently expressed in diverse BC subtypes.