The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff ...

Dre Greenlaw practiced for the first time this week since he tore his Achilles in the Super Bowl. Here's what head coach Kyle ...

The San Francisco 49ers promoted CB Nick McCloud to the active roster from the team's practice squad and activated LB Jalen ...

Buffalo Bills offensive stars prepare to shine against the San Francisco 49ers' struggling defense in a critical AFC-NFC ...

The first snow is beginning to fall at Highmark Stadium ahead of the Buffalo Bills' Week 13 bout with the San Francisco 49ers ...

The Buffalo Bills will look to clinch the AFC East on Sunday with a win against the San Francisco 49ers in what's expected to ...

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

The San Francisco 49ers fell to 5-6 on the season in losing to the Green Bay Packers on Sunday. Top takeaways with Brock ...

On Saturday, the San Francisco 49ers announced the following roster moves ahead of Sunday's snowy game in Buffalo against the ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

The National Weather Service has extended its "lake effect snow warning" in Buffalo through Monday at 7 p.m. ET, with ...

The San Francisco 49ers had a chance to move to 6-4 on the season last week at home against the Seattle Seahawks. They blew ...