We revealed that H3N2 CIV experiences greater selection pressure with extremely high global non-synonymous to synonymous substitution ratios per codon (dN/dS ratio) for each gene compared to the avian ...

was recoded with 631 synonymous mutations to give a codon pair bias ∼4.5-fold lower than that of wild-type poliovirus. The attenuated virus was further manipulated by recombining segments of ...

Using this data, we were able to identify the set of synonymous mutations for each codon. Change in mode of epistasis due to synonymous mutation in an extrinsic codon For any background in DHFR gene, ...

2019) and frequent gene rearrangements (Kumar et al., 2020; Tyagi et al., 2020; Li et al., 2021). However, other mitogenomic features of the RTA clade (e.g., nucleotide composition, codon usage, and ...

Yale researchers have created "Ochre," a genomically recoded organism that enables the production of synthetic proteins with novel properties, paving the way for groundbreaking applications in ...

A codon is a sequence of three nucleotides in ... "A lot of these words are equivalent, or synonymous," Grome said. "We set out to add more ingredients for building proteins, so we took three ...

Synthetic biologists from Yale were able to re-write the genetic code of an organism — a novel genomically recoded organism (GRO) with one stop codon — using a cellular platform that they developed ...

A Lower Manhattan neighborhood has outgrown the eatery that brought it to the world’s attention. Tribeca Grill, at 375 Greenwich Street, will sound “last call” for the last time on March 1. Corporate ...

Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM.