Researchers at The University of Texas MD Anderson Cancer Center have identified a potential breakthrough in the fight ...

"This is the first mouse model with truly humanized telomeres because telomerase isn't expressed in adult tissues in this model," Zhu said. "Our paper demonstrates that they exhibit human-like ...

Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is ...

Continually proliferating cells maintain adequate telomeres through the action of the reverse transcriptase telomerase. Telomeres are important to human health because dysregulation of either telomere ...

“This is the first mouse model with truly humanized telomeres because telomerase isn’t expressed in adult tissues in this model,” Zhu said. “Our paper demonstrates that they exhibit human ...

Figure 1: Expression of pRb and p16 as a function of cell density. Figure 3: hTERT clones undergo normal growth arrest in response to PALA and γ-irradiation. Figure 4: hTERT clones arrest ...

A briefing document (PDF) published by the FDA reviewer ahead of the adcomm has questioned the efficacy seen with the telomerase inhibitor, suggesting that the data doesn’t point to a disease ...

Geron Corporation (Nasdaq: GERN), a commercial-stage biopharmaceutical company, today announced that members of the management team are scheduled to p ...

The three were honored for “for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.” According to the Royal Swedish Academy, this year’s Nobel Prize in Physiology or ...

More information: Fan Zhang et al, Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length, Nature Communications (2025). DOI: 10.1038/s41467-025 ...