including tests on cell cultures expressing recombinant COX-1 or COX-2 enzymes and whole-blood assays measuring the production of either thromboxane by platelets (an index of COX-1 activity ...
The currently available antiplatelet drugs target key steps of platelet activation including thromboxane A 2 synthesis, ADP-mediated signaling, and glycoprotein IIb/IIIa-mediated platelet aggregation.