Ubiquitin is an intracellular signalling molecule that is conjugated to various proteins. Ubiquitin conjugation to itself yields Lys- or Met-conjugated chains, thus expanding its repertoire of ...

This poster introduces the background of Ubiquitins, applications of Ubiquitins in research, and featured active Ubiquitins ...

Figure 1: Discovery of the ligation of ubiquitin to lysozyme, a substrate of the proteolytic system. As indicated before 19, the main lesson from our story is the continued importance of the use ...

A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the tumor microenvironment (TME) and driving cancer progression. The study ...

E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

HEFEI, China I February 25, 2025 I Kangpu Biopharmaceuticals, Ltd. ("Kangpu") today announced that the Company has received IND approval from the CDE (Center ...

During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small protein called ubiquitin to other proteins. This tagging, in turn, helps determine the fate of the targeted ...

Most of our prior work focused on the Ubl protein SUMO as it is essential in budding yeast and its conjugation to substrates requires an enzyme cascade that involves fewer factors in comparison to the ...