论文摘要指出，癌症干细胞（CSCs）在癌症进展、免疫逃逸、耐药性和复发中起着关键作用。该研究发现肉碱棕榈酰转移酶 1A（CPT1A）在卵巢癌干细胞中高表达，且对维持其干性至关重要。CPT1A 通过调节脂质去饱和，促进线粒体裂变因子（MFF）的琥珀酰化，进而影响线粒体相关膜（MAMs）的形成和 SREBP1/SCD1 信号轴的激活。抑制 CPT1A 的赖氨酸琥珀酰转移酶（LSTase）活性，可降低 ...

The disruption of this crosstalk between IL-3 and IL-3Rα induces lipid metabolic reprogramming of microglia evidenced by upregulating CPT1A expression, a rate-limiting enzyme for the ...

Xiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, China ...

The mammalian circadian timing system and metabolism are highly interconnected, and disruption of this coupling is associated with negative health outcomes. Krüppel-like factors (KLFs) are ...

For ABCA1 and ABCG1 Western blots, the heating step was omitted. Primary antibodies directed against ABCA1 (#NB400105SS, Novus Biologicals), ABCG1 (#13578-1-AP, Proteintech), CPT1A (#15184-1-AP, ...

Currently, no systematic analyses on the role of succinylation regulators in tumors have been reported. In this study, we performed a comprehensive pan-cancer analysis on four well-known succinylation ...

Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ...