Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved catabolic process that ...

Here, we found that inhibition of AMPK occurs during naïve transition with two conventional inhibitors of the MEK1 and GSK3β pathways. The accumulation of glycogen due to iGSK3β is responsible for ...

Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD), which is characterized by a series of abnormal changes such as glomerulosclerosis, podocyte loss, renal tubular atrophy ...

（二）实验试剂 实验使用纯度超 98% 的 PrP106 - 126 肽，其序列为 KTNMKHMAGAAAAGAVVGGLG，同时设置乱序序列作为对照。鸢尾素、AMPK 激活剂 AICAR、AMPK 抑制剂 Compound C、蛋白酶体抑制剂 MG132 等试剂均购自相应公司，并按实验要求配置成不同浓度使用。 （三）质粒与转染 ...

This month's cover highlights the article Organotypic culture of human brain explants as a preclinical model for AI-driven antiviral studies by Emma Partiot, Barbara Gorda, Raphael Gaudin and ...

Here, the authors developed a cell-based screening assay for the identification of small molecule inhibitors of nonsense-mediated decay (NMD), and used it to validate KVS0001, a new small molecule ...

David Pastrnak’s early season slump has been behind him for some time. But since the turn of the new year, he’s re-emerged as one of the NHL’s best scorers. Pastrnak’s 14 lamp-lighters ...

Michael Boyle is an experienced financial professional with more than 10 years working with financial planning, derivatives, equities, fixed income, project management, and analytics. The idea of ...

YORK, Pa. (WGAL) — In York County, a Spring Garden Township man is being honored for his contributions to the Tuskegee Airmen. Second Lt. Lloyd Carter, who was killed in a plane crash in June ...