Peptides, as versatile biomolecules, continue to gain traction in various scientific fields due to their wide range of ...

Cryo-EM analysis of membrane-bound BAR protein endophilin B1 reveals how reorganization of amphipathic regions drive membrane permeabilization and contribute to Bax-mediated apoptosis ...

研究者使用冷冻电子显微镜、AlphaFold24和基于分子动力学的改进的综合方法，在大多数区域展示了亚纳米分辨率的apoB100的结构。该结构由一个大的球状N端结构域和一个约61纳米长的连续两亲β片组成，该β片像带一样包裹着LDL颗粒。准对称分布在β带两侧的是9个战略性的链间插入物，它们延伸到脂质表面，通过远程相互作用的网络提供额外的结构支持。

Apoptosis and autophagy constitute the two self-destructive processes by which supernumerary, damaged or aged cells and organelles are eliminated. Beyond this homeostatic function, autophagy is ...

Bacteriophage lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages during the final stage of the lytic cycle to enable cleavage through the host’s ...

The phospholipid bilayer nanodiscs (LNDs), as a rapidly-developing tool in recent years, provide a natural bio-memebrane environment to maintain the native conformation and functions of membrane ...

State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China University of Chinese Academy of Sciences, Beijing 100049, China ...

Department of Supramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry, Leiden University, PO Box 9502, Leiden, 2300 RA, The Netherlands ...