Nature22y
The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains
Bcr-Abl is found in more than 95% of cases with CML. The mechanism of Bcr-Abl-induced transformation is not fully understood. Bcr-Abl is a constitutively active tyrosine kinase with transforming ...
Nature22y
Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors
IL-3 protects p210 Bcr-Abl-transformed 32D and Baf3 cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors During our preliminary studies with PD180970, we found that the viability of ...