They found a significant decrease in a signaling pathway called Wnt/beta-catenin, which helps maintain the health of the ...

Next, they tested whether silencing the activity of mutant-beta-catenin would affect immune cell infiltration, by using 3D tumor spheroids from two different liver cancer cells lines. This showed ...

Beta catenin meanwhile is a signalling protein in the Wnt/Wingless pathway – in particular a downstream transcription factor (TCF) implicated in a range of solid tumour types including ...