Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors in the world, and its incidence and mortality have ...

They found a significant decrease in a signaling pathway called Wnt/beta-catenin, which helps maintain the health of the ...

A growing body of research highlights the crucial role of the Wnt signaling pathway, especially its β-catenin axis, in HCC. This pathway regulates essential processes such as cell proliferation, ...

Next, they tested whether silencing the activity of mutant-beta-catenin would affect immune cell infiltration, by using 3D tumor spheroids from two different liver cancer cells lines. This showed ...

Beta catenin meanwhile is a signalling protein in the Wnt/Wingless pathway – in particular a downstream transcription factor (TCF) implicated in a range of solid tumour types including ...

Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors in the world, and its incidence and mortality have increased year by year. HCC research has increasingly focused on ...