The mechanism of action of bupropion is unknown, as is the case with other antidepressants. However, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms.

If you may be or can become pregnant, it’s important to consider whether bupropion hydrochloride ER is a safe option for you. It isn’t known whether the SR and XL forms of bupropion ...

Objectives. To identify predictors of smoking abstinence at the end of medication use that could assist in the optimal use of a sustained-release (SR) form of bupropion for treating cigarette smokers.