CD19, a B-cell surface protein, is expressed across B-cell development and it is expressed on almost all B-cell malignancies, such as ALL, chronic lymphocytic leukemia (CLL) and several non ...

To address limitations with CAR T therapies targeting CD19, Allogene Therapeutics Inc. has developed ALLO-329, a ...

Fast Track designation is designed to expedite clinical development and regulatory review timelinesEnrolling patients in the GLEAM trial for ...

▎药明康德内容团队编辑Incyte日前在今年的美国血液学会（ASH）年会的摘要中，公布其CD19靶向单抗Monjuvi（tafasitamab）在关键性3期临床试验inMIND中获得积极结果。分析显示，tafasitamab联合来那度胺（len）和C ...

非霍奇金淋巴瘤（NHL）是一组淋巴造血系统恶性肿瘤的统称，其中以弥漫大B细胞淋巴瘤（DLBCL）最为常见。DLBCL病理类型复杂，临床亚型众多、可表现出不同的预后结局。对化疗敏感的复发/难治性DLBCL患者进行大剂量化疗后自体造血干细胞移植（HD-A ...

产品名称： iFluor 549重组抗小鼠 CD19 单克隆抗体 (克隆号1D3) | 悉得（Syd Labs） PA007374 英文名： iFluor 549 Recombinant Anti-mouse CD19 Monoclonal ...

Approval of the CD19 chimeric antigen receptor T-cell therapy (CAR T) — which, according to Autolus, was specifically “designed to have a ‘fast-off’ kinetic” to minimize excessive ...

In CAR-T therapy, CD19 is now the most extensively used target. It has been confirmed to be effective and safe for the treatment of CLL, B-ALL and B cell lymphoma. FMC63, an IgG2a mouse monoclonal ...

Nkarta’s pivot from oncology to autoimmune disease has continued with the biotech halting work on its CD19-directed CAR NK in lymphoma to focus on lupus. Seven patients with heavily pretreated ...

“These preclinical data show that CLN-978 is a highly potent T cell engager that leads to deep B cell depletion, supporting the broad development of CLN-978 as a potential new therapeutic option ...