TAB08 is a mAb that targets the key co-stimulatory receptor CD28 on T lymphocytes. Unlike with other drugs, binding of TAB08 to CD28 allows direct activation of T cells with only tonic T cell ...

The mAb also promotes unfettered binding of the T-cell CD28 receptor to the antigen-presenting cell receptor B7, together with antigen presentation to the T-cell receptor (Fig. 1). Such 'co ...