1 Department of Pharmacy, The Affiliated Yixing Hospital of Jiangsu University, Yixing, China 2 Department of pharmacy, Jiangsu Province Hospital, Nanjing, China Immunotherapy has become a global ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window HOUSTON -- Two-thirds of patients with PI3K-mutant brain metastases responded to the maximum tolerated dose (MTD ...

程序性死亡受体-1（PD-1）的基因于1992年由日本科学家Honjo在小鼠中分离、鉴定，在经历细胞死亡的T细胞杂交瘤中发现，因此得名。PD-1与CTLA-4、CD28和KIRs的结构具有相似性，人们因此猜测PD-1的配体可能是B7或MHC I家族成员。在2000年和2001年，Honjo和Freeman先后发现了PD ...

程序性死亡受体-1（PD-1）的基因于1992年由日本科学家Honjo在小鼠中分离、鉴定，在经历细胞死亡的T细胞杂交瘤中发现，因此得名。PD-1与CTLA-4、CD28和 ...

The YMNM cytoplasmic motif found in human CD28, which contains motifs for the binding of PI3K (YxxM) and GRB2/GADS (YxNx) is conserved in lungfish, sterlet, and spotted gar. In teleosts, the motif is ...

这一翻译控制通路可在T细胞活化后通过CD28-PI3K-mTORC1-eIF4F轴增强AMBRA1翻译，调节FAS和其他免疫相关基因的表达。 进一步，科研人员利用一系列蛋白互 ...

Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 30044, Taiwan, R.O.C Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei ...

T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of ...

38 Nevertheless, studies using proteomic analysis have confirmed AKT phosphorylation in FL samples, which is indicative of PI3K pathway activation. 39,40,42,43 Additional evidence for the ...