目前，MS 的发病机制仍是医学界亟待解开的谜题。已知它涉及针对髓鞘抗原的自身免疫反应，其中辅助性 T 细胞 4（CD4 + T 细胞），尤其是 Th1 和 Th17 亚群，在推动疾病进展中 “扮演” 着重要角色。然而，细胞毒性 T 细胞 8（CD8 + T 细胞）在 MS 和实验性自身免疫性脑脊髓炎（Experimental Autoimmune ...

Memorial Sloan Kettering Cancer Center researchers have found RNA neoantigen vaccines that generate long-lived, functional ...

Clinical trials planned to begin patient enrollment during 2025 to evaluate Gylden’s T cell Priming (TcP) candidates against Dengue (Phase II) ...

引言在肿瘤学的"无人区"，胰腺癌始终是医生手中的一根刺——它隐秘而凶险，确诊时大多已转移，五年生存率长期困在12%的魔咒中。更令人绝望的是，这种拥有钢铁般微环境的肿瘤对免疫治疗近乎"绝缘"，90%的PD-1抑制剂临床试验在此折戟。但2月19日《Nature》的一项里程碑研究“RNA neoantigen vaccines prime long-lived CD8+ ...

OVA peptide 即卵清蛋白肽，通常指卵清蛋白（Ovalbumin, OVA）中的特定肽段12。以下是常见的 OVA peptide 及其相关多肽信息 平台声明：该文观点仅代表作者本人，搜狐号系信息发布平台，搜狐仅提供信息存储空间服务。

In the direct pathway of allorecognition, intact donor Major Histocompatibility Complex (MHC) molecules are recognised on the surface of donor cells. Conversely, donor MHC can be internalised and ...

1School of Basic Medical Science, Southern Medical University, Guangzhou, China. 2Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 3Zenith Institute of ...

1Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 2Department of Breast and Thyroid Surgery, The First ...

Given the MHC-I and MHC-II associations with human SpA spectrum disorders ... Bulk RNAseq highlights the presence of clonal populations in both CD4+ and CD8+ conventional T-cell populations with the ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

CD8 + T cells can recognize and then kill HIV-infected cells following the presentation of fragments of viral proteins (epitopes) in the peptide-binding groove of MHC class I molecules on the ...

The innate immune system provides a crucial first line of defense against invading pathogens, and in addition, activates and guides subsequent adaptive immune responses. Although the role of innate ...