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生物谷
21 天
Nat Immunol:CyTOF技术助力解析适应性免疫反应的动态变化
CyTOF识别出流感特异性 T细胞,包括识别NP蛋白和PA蛋白表位的CD8 + T细胞,以及扩张的Vβ14 + CD4 + T细胞和Vβ9 + Treg 细胞。最后,研究人员探讨了预防性 ...
腾讯网
29 天
Immunity|组织驻留Treg:定植特化模型vs 泛组织模型
抗原经历的记忆T细胞会长期甚至无限期停留在抗原暴露组织,一旦抗原再次出现迅速做出应答反应。近几年,多篇文献报道组织驻留Treg的重要作用【3】,例如脂肪Treg的维持机体代谢稳态作用【4,5】、肌肉Treg参与肌肉修复【6】、脑Treg驱动少突胶质细胞分化 ...
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