CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

The CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about ...

No doubt 2025 will usher in many more advances in CRISPR therapies, thanks to the FDA’s new Platform Technology Designation ...

Figure 2. HBV replication and life-cycle in hepatocytes. Upon infection of hepatocytes, the HBV rcDNA is released into the nucleus and converted into cccDNA, which serves as the template for the ...

In parallel, the emergence of clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR-Cas9) revolutionized the field of genome engineering, allowing the ...

Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform ...

The CRISPR/Cas9 gene-editing system, based on a bacterial immune response against viruses, has been applied to human genome editing and was recently implemented in the first Food and Drug ...

By Balambal Suryanarayanan CRISPR-Cas9 is a repurposed gene editing tool that allows scientists to cut, replace, and insert pieces of DNA in precise regions along the strand. Courtesy of NIH Image ...

“They may be breaks that are induced by your gene-editing system, but they can also ... and Novartis – first conducted CRISPR-Cas9-based gene-editing of five well-studied genetic targets using two ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...