CRISPR-Cas systems are prokaryotic immune systems that confer resistance to foreign genetic elements such as plasmids and phages. CRISPR-Cas systems have been exploited for targeted genome editing ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

LETI-101 has demonstrated therapeutically relevant reductions of mutant huntingtin (HTT) protein, exceeding 80%, while preserving essential ...

In addition, first-generation CRISPR systems (Cas9 and Cas12a) are too large for efficient in vivo delivery via a single adeno-associated viral (AAV) vector. Now, new preclinical research ...

Gene editing stands for the methods to precisely make changes to a specific nucleic acid sequence. With the recent development of the clustered regularly interspaced short palindromic repeats (CRISPR) ...

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1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900 USA 2Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical ...

Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), Institute of Interdisciplinary Studies, College of Chemistry and Chemical Engineering, Hunan Normal ...

"Improper signature verification in AMD CPU ROM microcode patch loader may allow an attacker with local administrator privilege to load malicious CPU microcode resulting in loss of confidentiality and ...

Owners could be forced to keep pets indoors or, in some cases, prohibited from owning them, to protect wild animals SNP ministers are to consider banning pet cats, in a bid to protect birds and ...