Clopidogrel is a prescription drug used to reduce the risk of heart attack and stroke. Learn about the common, mild, and ...

DONCASTER and Bassetlaw Teaching Hospitals has been named as one of just four NHS sites in England selected to test a new ...

Specifically, compared to non-pregnant women, the activity of cytochrome P450 (CYP) enzymes that metabolize SSRIs drastically changes (e.g., decreased CYP2C19 activity and increased CYP2D6 activity).

Clopidogrel, an antiplatelet prodrug, requires activation by CYP enzymes to inhibit platelet activation. Clopidogrel resistance, affecting 4-30% of patients, is often due to CYP2C19 gene variations, ...

PPIs, especially omeprazole and esomeprazole, rely on the cytochrome P450 2C19 (CYP2C19) enzyme for processing and inhibit it. Asians also are genetically slower CYP2C19 metabolizers which may ...

Pharmacogenomic (PGx) testing has emerged as an effective strategy for informing drug selection and dosing. This has led to an increase in the use of PGx testing in the clinic and has catalyzed the ...