This three-step pathway involves the enzymes carboxylesterase, cytidine deaminase and thymidine phosphorylase (Figure 1), all of which are expressed in hepatic and tumor tissue. In particular the ...

Centre for Inflammation Research, The University of Edinburgh, Edinburgh EH16 4UU, U.K. IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, U.K.