The boronic acid transition state inhibitors S-02030 and MB-076 were strategically designed to be active against cephalosporinases and carbapenemases, especially KPC (Klebsiella pneumoniae ...

For bloodstream infections caused by chromosomal AmpC β-lactamase-producing strains, cefepime may be an appropriate carbapenem-sparing treatment option. Cefepime is supported as an alternative to ...