引言在生命科学领域，细胞身份（cell identity）的稳定性始终是个迷人而危险的谜题。就像精密运作的宇宙飞船需要严格的门禁系统，每个细胞都携带着决定其功能的基因密码。但当这种"基因门禁"失效时，细胞会陷入身份混乱——这正是癌症发生的核心机制之一。近年研究发现，细胞命运可塑性（cell fate ...

The nucleus needs to be reprogrammed for cells to differentiate into new cell types. During this process, chromatin is seen to be re-organizing itself in a way that is thought to turn on new gene ...

Masters of cell fate It’s a much less complicated system than Dr. Stephen Tapscott, who led the study, had anticipated. Faced with the incredible variety of structure and composition of proteins, he ...

Messenger RNA can travel between different types of stem cells through tunnel-like structures, as revealed by a new study. By studying interactions between mouse and human stem cells, they discovered ...

The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development. During development, cells differentiate into various cell types with distinct functions. To understand ...

Sister cells are a pair of cells that share the same mother cell. In a new study published in Developmental Cell, researchers ...

Sensory neurons of the peripheral nervous system and NC-derived melanocytes — Left panel: Cells differentiating into pain-sensing neurons. Middle panel: Immature neurons of the trigeminal nerve ...

Tang and Anna Vähärautio, a cancer biologist at the University of Helsinki and coauthor of the study, wanted to develop a method that combined lineage tracing—the process of tracking cell fate and ...

Currently, FATE leverages induced pluripotent stem cells [iPSCs] and other advanced gene editing techniques that offer a unique spin on CAR T and NK cells. Also, I like their scalable and off-the ...

The reason melanoma is the deadliest form of skin cancer stems from the curious ability of all of its cells to swap fates, according to a study publishing in __Cell__ ...

Epithelial tissues are in constant interaction with their environment. Maintaining their functionality requires dynamic balance (homeostasis) and that their cell numbers are tightly regulated.