Hosted on MSN2mon
Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find
A new paper from MUSC Hollings Cancer Center researchers is helping to reveal the "rules" for engineering chimeric antigen receptor (CAR) Tregs. Tregs, or T-regulatory cells, have shown promise in ...
The American Journal of Managed Care2d
Allogeneic vs Autologous CAR T-Cell Therapy Explained
Allogene Therapeutics published new long-term follow-up data on cemacabtagene ansegedleucel, showing the investigative ...
Nature22d
A compound chimeric antigen receptor strategy for targeting multiple myeloma
Current clinical outcomes using chimeric-antigen receptors (CARs) against multiple myeloma show promise in the eradication of bulk disease. However, these anti-BCMA (CD269) CARs observe relapse as ...
The New England Journal of Medicine21d
CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53
Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...
The Facts13d
Restore Vision Announces First Patient Dosed in Phase I/II Clinical Trial of RV-001 for Gene-Agnostic Retinitis Pigmentosa
The first optogenetic "Chimeric Rhodopsin" gene therapy tested in humans.RV-001 starting dose was generally well tolerated in this open-label trial.RV-001 a gene-agnostic approach for RP patients.