Results Nine arginine residues within FBG were citrullinated by PAD2 and PAD4. Two immunodominant peptides cTNC1 (VFLRRKNG-cit-ENFYQNW) and cTNC5 (EHSIQFAEMKL-cit-PSNF-cit-NLEG-cit-cit-KR) were ...

The RA at-risk cohort included people with serological evidence of IgG ACPA (anticyclic citrullinated peptide (CCP) and/or antimodified citrullinated vimentin (anti-MCV) antibodies) with or without ...

Objective: To investigate the expression and activity of four isotypes of PAD in peripheral blood and synovial fluid cells of patients with RA. Conclusion: PAD2 and PAD4 are the most likely candidate ...

Levels of C3, anti-cyclic citrullinated peptide (CCP) antibody, or anti-mutated citrullinated vimentin (MCV) antibody were similar among the three groups. (Table 1) Although the absolute number of ...

Possible links between cell types or above-reported cytokines and chemokines and their effects will be described (see figure 1). The ACPA against vimentin was shown to be sialylated. This is ...

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation and bone erosion. The exact mechanism of RA is still unknown, but various immune cytokines, signaling pathways and ...

Additionally, CRISPR/Cas gene editing was applied to healthy stem cells to study the roles of GFAP and vimentin. The absence of both proteins impaired organoid development, particularly in the cortex.

An ANA blood test (antinuclear antibody test) is usually performed on a blood sample as part of the diagnostic process for certain autoimmune diseases. It is usually ordered along with other blood ...