Objective: The purpose of the present study was to demonstrate clinical equivalence between the application of collagenase ointment at 24- and 48-hour intervals in the healing of pressure ulcers.

Collagen, one of the most abundant proteins of vertebrate tissues, is the major component of connective tissues such as skin, tendon and bone. In the living organism collagen is present almost ...

We have examined various possible methods for avoiding these difficulties and have found that the substitution of collagenase for trypsin satisfied most of our requirements.