A combined pharmacokinetic model was developed and fitted concurrently ... Standard 1-, 2-, and 3-compartment models were fitted to the concentration-time data for the combined intravenous and ...

a population pharmacokinetics model of polymyxin B with the Phoenix NLME program was developed in our study. A total of 151 plasma samples from 50 patients were collected in the present study.

Results: The pharmacokinetics of intravenous fentanyl reflected a 2-compartment model with a clearance of approximately 1.5 L/min. There was moderate (< 50%) between-subject variability (BSV ...

The primary endpoint was to evaluate the safety, tolerability, and pharmacokinetic (PK) profiles of a subcutaneous injection of ... The PK profile of AK111 was well described by a one-compartment ...

Recently published study focused on the evaluation of a novel etomidate analogue, methoxyethyl etomidate hydrochloride (ET-26), in healthy volunteers to assess its safety, tolerability, ...

Mydriatic microdrops are noninferior to standard drops of a diluted mydriatic mixture when used in infants being screened for ROP.

Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB), MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States ...

The importance of pharmacokinetic (PK) and pharmacodynamic (PD ... affecting the design and conduct of paediatric pharmacological studies can be overcome using targeted pharmacometric strategies.

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They were the world's first supermodels, after all. But if you’re wondering how to become a model nowadays, a lot has changed since the ’90s—not least the introduction of the internet and ...

Tesla TSLA.O launched a redesigned version of its best-selling Model Y crossover in the United States, Canada and Europe on Thursday, weeks after it was first released in China. The refreshed ...