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Advanced Science | 刘聪与合作者开发单分子方法揭示化学分子调控...
本研究通过光镊实验,发现α-syn纤维是一种高度刚性的生物聚合物,且其形变和断裂特性具有显著的异质性。传统方法(如酶切,超声等)通常得到的是大量纤维平均后的稳定性信息,而本研究提供了单根纤维的力学测量结果,揭示了单根纤维在力学稳定性上的显著差异。这一 ...
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