This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, China ...

Methods: In this study, we developed a recombinase polymerase amplification (RPA) combined with CRISPR/Cas12a assay, specifically targeting the FAdV-4 Hexon gene. RPA and CRISPR/Cas12a reagents were ...

Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), Institute of Interdisciplinary Studies, College of Chemistry and Chemical Engineering, Hunan Normal ...

A team of researchers from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has developed a point-of-care testing (POCT) system based on microfluidic CRISPR-Dx technology, ...

Additionally, Editas Medicine management will participate in the following upcoming investor conferences in March: To access the live webcasts of Editas Medicine’s presentations, please visit the ...

Conventional CRISPR nucleases, including Cas9 and Cas12a, exceed the packaging limits of a single AAV vector, necessitating ...

Study advances gene-editing capabilities for cancer and medical research through genetic manipulations using Cas12a enzyme ...

In addition, first-generation CRISPR systems (Cas9 and Cas12a) are too large for efficient in vivo delivery via a single adeno-associated viral (AAV) vector. Now, new preclinical research ...

本报讯（刘进毛旭建姚瑶）近日，江苏省卫生健康委员会公布2024年度医学科研立项项目名单，《基于CRISPR技术的新型HIV基因型耐药筛查方案的构建及其临床应用研究》获重点项目支持，该项目由市疾控中心病原生物检验科王凤鸣研究员主持。

tsmedizin Halle, Martin Luther University Halle-Wittenberg）的研究人员探究了靶向 RNA 的 CRISPR 系统 Cas13d 在 GI 图谱绘制中的效用，并将其与常用于 GI 图谱绘制的两种 DNA 核酸酶 Cas9 和 Cas12a 进行了比较。研究人员发现，与 Cas9 或 Cas12a 相比，Cas13d 能更快地诱导靶基因扰动 ...