The Genome Editing Market is expected to grow significantly due to advancements in gene therapy technologies and the increasing demand for genetically modified organisms (GMOs) in agriculture and ...

This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...

该工作系统研究了AsCas12f1及其改进型突变体对靶DNA切割过程的动力学分子机制。研究发现，AsCas12f1解旋原间隔区内DNA后，在非靶链DNA上产生缺口（nick）并进行双向外切模式的核酸降解；随后，AsCas12f1把DNA解旋范围扩展到 ...

Editas Medicine与Genevant Sciences宣布达成一项合作和非排他性许可协议，双方将结合Editas的CRISPR Cas12a基因组编辑系统与Genevant的专有脂质纳米颗粒（LNP ...

CRISPR-Cas基因编辑技术在基础研究 ... 除了广为人知的II型Cas9蛋白外，V型Cas12家族（如Cas12a至Cas12n）也逐渐被发掘。尽管多种Cas12蛋白已被鉴定 ...

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area Delle Scienze 17/A, 43124 Parma, Italy ...

Harbinger developed a novel CRISPR/Cas12a-based method depleting unmethylated CpG sites at precise locations, in non-cancerous cfDNA. The remaining DNA is enriched for methylated, ctDNA molecules.

A pipeline for the analysis of CRISPR edited data. It allows the evaluation of the quality of gene editing experiments using targeted next generation sequencing (NGS) data (`targeted`) as well as the ...

"Unlike the well-known CRISPR gene-editing system, often described as molecular 'scissors,' the newly studied type IV-A CRISPR system does not cut genes. Instead, it uses an RNA-guided 'effector ...

该研究开发了一种基于CRISPR-Cas13的靶向RNA的转录组规模的CRISPR筛选技术，并使用该技术在来自不同组织的5种人类细胞中筛选鉴定了778个必需的lncRNA。