It has two candidates in phase 3 – lurbinectedin for small-cell lung cancer and JZP351 (liposomal daunorubicin and cytarabine) for acute myeloid leukaemia. The deal is also a first partnership ...

为解决多药 ABC 转运蛋白工作机制细节不明的问题，多国研究人员聚焦 BmrA 展开研究。发现 R6G 和 H?chst33342 可窄化 BmrA 构象范围，提升 ATP 利用效率。该成果有助于理解微生物耐药机制，推荐科研读者一读。

Acute myeloid leukemia (AML) is a complex and heterogeneous group of aggressive hematopoietic stem cell disease. The presence of diverse and functionally distinct populations of leukemia cells within ...

The dominant rationale to generate new (and to assess old) anticancer chemotherapeutic agents is to determine their cell-autonomous effects — that is, their capacity to reduce the growth ...

The term "chemo curls" is used to describe changes in your hair following chemotherapy treatment for cancer. Chemo often leads to hair loss as one of the side effects, and many people report that ...

The effects of chemotherapy can continue after treatment or even develop years later. These include effects on the brain, heart, bones, nervous system, lungs, and other systems. Chemotherapy is ...

1 Frequency of emesis in the absence of effective antiemetic prophylaxis. 2 May be highly emetogenic in certain patients. 3 Routine premedication may not be required. An individualized approach is ...

Hypoxia-inducible factors (HIFs), central regulators for cells to adapt to low cellular oxygen levels, are often overexpressed and activated in breast cancer. HIFs modulate the primary transcriptional ...