Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers ...

These functions are localized to the C-terminal region and are dependent on FHR-B dimerization. Dimerization occurs through the N-terminal region (SCR1-3), which differs from mFH SCR5-7 by only four ...

Northwestern University researchers have identified structural features in engineered cell receptors that correlate with ...

Merck Sharp & Dohme LLC has identified targeted activator of cell kill (TACK) compounds acting as Gag polyprotein (HIV-1)/protein Pol dimerization inducers reported to be useful for the treatment of ...

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This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to efficiently activate innate immunity while avoiding ...

DURING the past four years we have been investigating the mechanism of two closely allied reactions—the polymerization of isobutene and the dimerization of di-isobutene. Both these reactions are ...

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Here, the authors show how the dimerization of synthetic transmembrane DNA receptors can be used to engineer sensing and actuation cascades in response to external molecular signals. Actin in ...