and phase-II (conjugating) enzymes have been extensively studied. This review introduces the concept of pharmacogenetics in the context of drug-metabolizing enzymes and highlights the ...

and dissertations with search terms including each drug and drug metabolizing enzyme or transporter; each paper thus retrieved was reviewed by a minimum of two coauthors. Phase I enzymes catalyze ...

Proceeds will support testing of drugs designed to suppress hunger in people with the tough-to-treat rare disease and, ...

Lenacapavir, a twice yearly injection that prevents HIV transmission, was named the breakthrough medicine of 2024. But ...

Scientists discover that cancer treatment DCA may help endometriosis patients by targeting the disease's abnormal cellular metabolism ...

Faster-acting drugs have long been sought to protect people with severe depression who may be at risk of self-harm or suicide ...

With over 50 years of experience, Celerion specializes in Phase 1 studies, including first-in-human dose escalation, drug-drug interactions, cardiac safety, bioequivalence, metabolism, and ...

Aardvark’s lead candidate ARD-101 is being investigated in a Phase III study for hyperphagia in Prader-Willi syndrome.

Novo Nordisk announced plans for a longer phase III trial testing its investigational obesity drug CagriSema, with regulatory submission expected early next year. The FDA approved ranibizumab (Susvimo ...

GSK licensed the drug from long-standing partner Ionis as part of a two-drug deal in 2019, paying $25 million upfront with milestone payments taking the value of the deal up to $262 million.

Semaglutide — the active substance in Ozempic and Wegovy — may help reduce alcohol cravings in people with alcohol use ...