The evidence for the authors' claims is convincing, combining state-of-the-art conditional gene deletion in the mouse lens with histological and molecular approaches. This work should be of great ...

the researchers found that injecting the StitchR-enabled ΔH2-R15 gene restored the amount of ΔH2-R15 to levels comparable to the dystrophin protein levels of the control mice, and it restored ...

Our records of the human genome may still be missing tens of thousands of 'dark' genes. These hard-to-detect sequences of genetic material can code for tiny proteins, some involved in disease ...

Researchers in Lithuania present the molecular structure of a new, more-versatile CRISPR system for gene editing. Scientists have unveiled a new version of the famous gene-editing tool CRISPR ...

Furthermore, it has been reported to modulate gene expression during different pathophysiological ... Echocardiography of each group of mice was performed every 2 weeks after EMPA administration to ...

Global EMCN knockout mice were generated by crossing EMCN-floxed mice with ROSA26-Cre mice ... Transcriptional profiles were analyzed to identify differentially expressed genes in both endothelium and ...

Gene therapy that selectively delivers the SMN1 gene to the liver reduced alterations related to spinal muscular atrophy (SMA) in a mouse model, restoring muscle size and correcting pancreatic issues.

The development of numerous genetically engineered mice that have had particular genes overexpressed or knocked out has made it feasible to investigate ... 3.1.10 Mononuclear phagocytes: innate immune ...

This important work advances our understanding of CHMP5's role in regulating osteogenesis through its impact on cellular senescence. The evidence supporting the conclusion is mostly convincing, ...