Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...
Collagen is the most abundant protein in the human body, playing a crucial role in providing structure to the skin, bones, tendons, and connective tissues. It is widely used in various industries such ...
The drug, named lenacapavir, targets the structure and function of HIV's capsid protein. It protects people for 6 months with each shot. Unlike mainstay HIV drugs that disrupt viral enzymes by binding ...
The award also recognizes related work surrounding gaining a new understanding of the structure and function of HIV's capsid protein. Despite decades of advancements, HIV continues to infect more than ...
While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they now discovered that these motors also put significant twists into the loops that they form.