CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

而在配对的肿瘤组织样本中，也能找到与外周血中基因特征高度一致，但尚未因抗原慢性刺激进入耗竭状态的KIR+CD8+T细胞，它们可能会在肿瘤微环境内发挥免疫抑制作用。研究者们又基于患者肿瘤新抗原数据构建了肿瘤相关抗原肽库，通过TCR转导细胞系，证实KIR+CD8+T细胞存在肿瘤抗原特异性，即能够被来自肿瘤的抗原激活。

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to ...

▎药明康德内容团队编辑  结直肠癌（CRC）是全球第三大常见癌症，其死亡率不断上升。美国FDA已批准使用免疫检查点抑制剂（ICI）治疗CRC，包括PD-1抑制剂，然而超过85%具有pMMR/MSS特征的患者几乎无法从中受益。癌细胞具有高度的代谢状态， ...

Dec. 11, 2024 — Gut microbiome composition during pregnancy has long-term effects on offspring stem cell growth and development, researchers report. Treating pregnant mice with a common gut ...

The ‘enrichplot’ package implements several visualization methods for interpreting functional enrichment results obtained from ORA or GSEA analysis. All the ...