而在配对的肿瘤组织样本中，也能找到与外周血中基因特征高度一致，但尚未因抗原慢性刺激进入耗竭状态的KIR+CD8+T细胞，它们可能会在肿瘤微环境内发挥免疫抑制作用。研究者们又基于患者肿瘤新抗原数据构建了肿瘤相关抗原肽库，通过TCR转导细胞系，证实KIR+CD8+T细胞存在肿瘤抗原特异性，即能够被来自肿瘤的抗原激活。

GSEApy is a Python/Rust implementation for GSEA and wrapper for Enrichr. GSEApy can be used for RNA-seq, ChIP-seq, Microarray data. It can be used for convenient GO enrichment and to produce ...

For in vivo GPX4 deletion, TAM was prepared and administrated as previously described (17). For in vitro GPX4 deletion, enriched CD8 + T cells from Gpx4 fl/fl-ERT2Cre-P14 mice were treated with 5 μM 4 ...

Cytotoxic T cells are CD8-postive T cells that are specialized for the direct killing of cells that are infected (particularly with viruses), cancerous or damaged in other ways. They express the ...

(C) Log2 fold-change of the inflammatory signaling pathway activity between endometriosis patients – E, and controls – C in the different cell-types defined in Shih. et al. Horizontal bars show ...

Tesla’s top battery cell supplier, CATL, is throwing some cold water on Tesla’s battery plans and the CEO even said that Elon Musk “doesn’t know how to make battery cells.” Contemporary ...

Called Vance, the global, multinational, randomised phase three trial, led by Singapore clinician-scientist Toh Han Chong, is the largest completed trial on T-cell therapy on any solid tumour.

AD samples were enriched in monocytes, CD8+ T cells, Tem/Temra cytotoxic T cells ... differentially expressed genes; GEO, Gene Expression Omnibus; GSEA, Gene set enrichment analysis; KEGG, Kyoto ...